General Chapter <795> Pharmaceutical Compounding—Nonsterile Preparations. In: United States Pharmacopeia and National Formulary (USP 43-NF 38). Revised January 1, 2014. Rockville, MD: The United States Pharmacopeia Convention Inc; 2020.
Commercially available as a 10-mg/mL solution — Use extemporaneously prepared formulation only when commercial product is unavailable or a more concentrated suspension is desired. Extemporaneously prepared suspension may not achieve same bioavailability as commercially available formulation. Monitoring of serum itraconazole concentration may be warranted.
JacobsonPA, JohnsonCE, WaltersJR.Stability of itraconazole in an extemporaneously compounded oral liquid. J Health Syst Pharm. 1995;52:189–191.
ChristensenKJ, GubbinsPO, GurleyBJ, et al.Relative bioavailability of itraconazole from an extemporaneously prepared suspension and from the marketed capsules. Am J Health Syst Pharm. 1998;55:261–265.10.1093/ajhp/55.3.261)| false