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Powder containment hood, mortar and pestle, graduated cylinder
Open capsules and empty contents into a mortar.
Triturate contents to a fine powder.
Levigate powder with a small amount of vehicle to form a paste.
Add vehicle in increasing amounts while mixing thoroughly.
Transfer contents of the mortar to a graduated cylinder.
Rinse the mortar and pestle with vehicle and pour into graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Special Instructions — Do not allow capsule content to soak in Ora-Blend before triturating.
Alternatives — May substitute vehicle with 12.5 mL of Ora-Plus mixed with 12.5 mL of Ora-Sweet.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For oral use only. Store in refrigerator. Shake well before use.
Storage Conditions/Stability — Refrigerate. Stable for 90 days.
Study Container Type — Amber polyethylene terephthalate (PET) and amber glass prescription bottle
Referenced Manufacturers — Aprepitant capsules (Emend, Merck & Co); Ora-Blend (Paddock Laboratories, LLC).
Stability-Indicating Study — Yes
Commercially available as a 25-mg/mL suspension — Use extemporaneously prepared formulation only when commercial product is unavailable or a more dilute solution is desired.
Dupuis LL, Lingertat-Walsh K, Walker SE. Stability of an extemporaneous oral liquid aprepitant formulation. Support Care Cancer 2009;17:701–706.
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