General Chapter <795> Pharmaceutical Compounding—Nonsterile Preparations. In: United States Pharmacopeia and National Formulary (USP 43-NF 38). Revised January 1, 2014. Rockville, MD: The United States Pharmacopeia Convention Inc; 2020.
Powder containment hood, mortar and pestle, graduated cylinder
Triturate tablets to a fine powder with a mortar and pestle.
Levigate powder with a small amount of vehicle to form a paste.
Add vehicle in increasing amounts while mixing thoroughly.
Transfer contents of the mortar to a graduated cylinder.
Rinse the mortar and pestle with vehicle and pour into graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Special Instructions — *Mix 60 mL of Ora-Plus with 60 mL of Ora-Sweet. Use mixture as vehicle or use Ora-Blend.
Alternatives — May substitute vehicle with 11 mL methylcellulose 1% (see page 107 for preparation directions) mixed with 109 mL simple syrup NF. Stable for 42 days when refrigerated and 28 days when stored at room temperature.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For oral use only. Store at room temperature or refrigerate. Shake well before use.
Storage Conditions/Stability — Store at room temperature or refrigerate. Stable for 91 days.
STABILITY STUDY DETAILS:
Study Container Type — Plastic bottle
Referenced Manufacturers — Not specified.
Stability-Indicating Study — Yes
NahataMC.Long-term stability of zonisamide, amitriptyline, and glycopyrrolate in extemporaneously prepared liquid-dosage form at two temperatures. Int J Pharm Compd.2016;20(2):164–166.
NahataMC.Long-term stability of zonisamide, amitriptyline, and glycopyrrolate in extemporaneously prepared liquid-dosage form at two temperatures. Int J Pharm Compd. 2016;20(2):164–166.)| false