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Chapter 10: Whole Molecule Drug Evaluation

Edited by Marc W. Harrold and Robin M. Zavod

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1 INTRODUCTION

Marc W. Harrold and Robin M. Zavod

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2 FUNCTIONAL GROUP CHARACTERISTICS AND ROLES

Marc W. Harrold and Robin M. Zavod

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3 IDENTIFYING ACIDIC AND BASIC FUNCTIONAL GROUPS

Marc W. Harrold and Robin M. Zavod

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4 SOLVING pH AND pKa PROBLEMS

Marc W. Harrold and Robin M. Zavod

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5 SALTS AND SOLUBILITY

Marc W. Harrold and Robin M. Zavod

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6 DRUG BINDING INTERACTIONS

Marc W. Harrold and Robin M. Zavod

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7 STEREOCHEMISTRY AND DRUG ACTION

Marc W. Harrold and Robin M. Zavod

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8 DRUG METABOLISM

Marc W. Harrold and Robin M. Zavod

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9 STRUCTURE ACTIVITY RELATIONSHIPS AND BASIC CONCEPTS IN DRUG DESIGN

Marc W. Harrold and Robin M. Zavod