Abciximab: AHFS 20:12.18

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Abciximab

AHFS 20:12.18

in ASHP® Injectable Drug Information™

DOI:: https://doi.org/10.37573/9781585287079.001

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Abciximab is available as a 2-mg/mL solution, which also contains sodium phosphate 0.01 M, sodium chloride 0.15 M, and polysorbate 80 0.001% in water for injection.³²⁷⁸

pH

7.2.³²⁷⁸

Trade Name(s)

ReoPro

Administration

Abciximab is administered by direct intravenous injection followed by continuous intravenous infusion using a controlled infusion device after dilution in sodium chloride 0.9% or dextrose 5%.³²⁷⁸

Stability

The clear, colorless injection in intact vials should be stored under refrigeration and protected from freezing.³²⁷⁸ The vials should not be shaken.³²⁷⁸ No incompatibilities with glass bottles or PVC containers and sets have been observed.³²⁷⁸

Although refrigerated storage is required, the manufacturer has stated that the drug may be stored at room temperature for 8 days.²⁷⁴⁵

Filtration

The manufacturer recommends filtration through a low protein-binding 0.2- or 5-μm syringe filter during preparation of an intravenous infusion or using a 0.2- or 0.22-μm inline filter during its administration.³²⁷⁸ The manufacturer also recommends using a low protein-binding 0.2- or 5-μm syringe filter for bolus doses.³²⁷⁸

Compatibility Information

Y-Site Injection Compatibility (1:1 Mixture)

Abciximab

Test Drug	Mfr	Conc	Mfr	Conc	Remarks	Ref	C/I
Adenosine	FUJ	3 mg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C
Argatroban	GSK	1 mg/mL^a ^b ^c	LI	36 mcg/mL^a ^b ^c	Physically compatible with no loss of argatroban in 4 hr at 23°C. Abciximab not tested	2630	C
Atropine sulfate	AMR	0.4 mg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C
Bivalirudin	TMC	5 mg/mL^a	CEN	10 mcg/mL^a	Physically compatible for 4 hr at 23°C	2373	C
Cangrelor tetrasodium	TMC	1 mg/mL^b		10 mcg/mL^b	Physically compatible for 4 hr	3243	C
Diphenhydramine HCl	ES	25 mg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C
Fentanyl citrate	AB	50 mcg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C
Metoprolol tartrate	AB	1 mg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C
Midazolam HCl	BED	2 mg/mL	LI	36 mcg/mL^a	Visually compatible for 12 hr at 23°C	2374	C

Tested in dextrose 5%.

Tested in sodium chloride 0.9%.

Mixed argatroban:abciximab 1:1 and 4:1.

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Table of Contents

Abciximab

AHFS 20:12.18

Products

pH

Trade Name(s)

Administration

Stability

Filtration

Compatibility Information

Y-Site Injection Compatibility (1:1 Mixture)

Abciximab

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