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Powder containment hood, glass mortar and pestle, graduated cylinder
Triturate tablets to a fine powder with a mortar and pestle.
Levigate powder with a small amount of vehicle to form a paste.
Add vehicle in increasing amounts while mixing thoroughly.
Transfer contents of the mortar to a graduated cylinder.
Rinse the mortar and pestle with vehicle and pour into graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Special Instructions — *Mix 60 mL of Ora-Plus with 60 mL of strawberry syrup NF. Use mixture as vehicle.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For oral use only. Store at room temperature or refrigerate. Shake well before use.
Storage Conditions/Stability — Store at room temperature or refrigerate. Stable for 57 days.
Study Container Type — Amber plastic prescription bottle with child-resistant cap
Referenced Manufacturers — Levofloxacin tablets (Levaquin, Ortho-McNeil Pharmaceutical); Ora-Plus (Paddock Laboratories, LLC); strawberry syrup NF (Lyons Magnus).
Stability-Indicating Study — Yes
Commercially available as a 25-mg/mL solution — Use extemporaneously prepared formulation only when commercial product is unavailable or a more concentrated suspension is desired.
VandenBussche HL, Johnson CE, Fontana EM, et al.Stability of levofloxacin in an extemporaneously compounded oral liquid. Am J Health Syst Pharm. 1999;56:2316–2318.
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