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Containment ventilated enclosure (CVE) or biological safety cabinet (BSC), 2 × 18-G needles, 1 × 10-mL syringe, 1 × 60-mL syringe, 1 × 0.22-µm filter needle
Caution: Hazardous Drug—Non-antineoplastic hazards: Must be prepared in compliance with USP <800>.
Withdraw volume of injectable solution using a 10-mL syringe.
Withdraw volume of sodium chloride 0.9% injection using a 60-mL syringe.
Add injectable solution into the syringe containing sodium chloride 0.9% injection.
Cap 60-mL syringe and mix well.
Change to a 0.22-µm filter needle.
Transfer the solution into an empty Viaflex bag.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. Caution: hazardous drug. For ophthalmic use only. Store in refrigerator.
Storage Conditions/Stability — Refrigerate. Stable for 5 days.
Study Container Type — Polyvinyl chloride or ethylene-propylene copolymer bag
Referenced Manufacturers — Cidofovir injection (Gilead Sciences, Inc); sodium chloride 0.9% injection (Abbott Laboratories; Baxter Healthcare Corp; McGaw, Inc).
Stability-Indicating Study — No
Ennis RD, Dahl TC. Stability of cidofovir in 0.9% sodium chloride injection for five days. Am J Health Syst Pharm. 1997;54(19):2204–2206.
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