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Laminar flow hood, 1 × 18-G needle, 1 × 3-mL syringe, 1 × 0.22-µm filter needle
Must be prepared in compliance with USP <797>.
Reconstitute injectable powder with 2 mL of artificial tears.
Withdraw volume of injectable solution using a 3-mL syringe.
Change to a 0.22-µm filter needle.
Transfer the cefazolin sodium solution into the ophthalmic bottle with the remaining artificial tears.
Shake well to mix.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For ophthalmic use only. Store in refrigerator.
Storage Conditions/Stability — Refrigerate. Stable for 28 days.
Study Container Type — Artificial tears dropper bottle
Referenced Manufacturers — Cefazolin sodium injection (Ancef, SmithKline Beecham Pharmaceuticals); artificial tears (Liquifilm Tears, Allergan, Inc).
Stability-Indicating Study — No
Charlton JF, Dalla KP, Kniska A. Storage of extemporaneously prepared ophthalmic antimicrobial solutions. Am J Health Syst Pharm. 1998;55(5):463–466.
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