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Powder containment hood, porcelain mortar and pestle, graduated cylinder
Triturate tablets to a fine powder with a mortar and pestle.
Levigate powder with Ora-Plus to form paste.
Add Ora-Plus in increasing amounts while mixing thoroughly.
Transfer contents of the mortar to a graduated cylinder.
Rinse the mortar and pestle with vehicle and pour into graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Alternatives — May substitute vehicle with Ora-Sweet SF or Syrpalta. It is not necessary to use Ora-Plus if Syrpalta is used as vehicle.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For oral use only. Store in refrigerator. Shake well before use.
Storage Conditions/Stability — Refrigerate. Stable for 21 days.
Study Container Type — Amber glass bottle
Referenced Manufacturers — Sumatriptan succinate tablets (Imitrex, Glaxo Wellcome, Inc); Ora-Plus, Ora-Sweet, Ora-Sweet SF (Paddock Laboratories, LLC); Syrpalta syrup (Humco).
Stability-Indicating Study — Yes
Fish DN, Beall HD, Goodwin SD, et al.Stability of sumatriptan succinate in extemporaneously prepared oral liquids. Am J Health Syst Pharm. 1997;54:1619–1622.
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