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Containment ventilated enclosure (CVE) or biological safety cabinet (BSC), 2 × 18-G needles, 2 × 60-mL syringes, graduated cylinder
Caution: Hazardous Drug—Antineoplastic drug: Must be prepared in compliance with USP <800>.
Withdraw volume of injectable solution using a 60-mL syringe.
Transfer the solution to a graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. Caution: antineoplastic drug. For oral use only. Store at room temperature. Shake well before use.
Storage Conditions/Stability — Store at room temperature. Stable for 22 days.
Study Container Type — 5-mL plastic oral syringe
Referenced Manufacturers — Etoposide injection (VePesid, Bristol-Myers Squibb); sodium chloride 0.9% for injection (Lyphomed, Inc).
Stability-Indicating Study — Yes
McLeod HL, Relling MV. Stability of etoposide solution for oral use. Am J Hosp Pharm. 1992;49(11):2784–2785.
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