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Measure the volume of morphine sulfate solution with a graduated cylinder.
Add vehicle to the graduated cylinder to achieve the total volume indicated above.
Transfer contents of the graduated cylinder into an appropriately sized amber bottle.
Shake well to mix.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For oral use only. Store at room temperature. Shake well before use.
Storage Conditions/Stability — Store at room temperature. Stable for 60 days.
Container Closure — Polypropylene plastic amber oval bottle
Referenced Manufacturers — Morphine sulfate solution (alcohol-free) (Roxane Laboratories, Inc); sterile water for irrigation (Baxter Healthcare Corp).
Stability-Indicating Study — No
Commercially available as a 2-, 4-, and 20-mg/mL solution — Use extemporaneously prepared formulation only when commercial product is unavailable or a more dilute solution is desired.
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