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Vancomycin hydrochloride 500 mg injection | 1 vial |
Sterile water for injection | 5 mL |
Artificial tears | QSAD: 15 mL |
Laminar flow hood, 3 × 18-G needles, 3 × 5-mL syringes, 1 × 0.22-µm filter needle
Must be prepared in compliance with USP <797>.
Reconstitute injectable powder with 5 mL of sterile water for injection.
Withdraw 4.6 mL of artificial tears from the 15-mL ophthalmic bottle and discard.
Withdraw 4.6 mL of vancomycin injectable solution using a 5-mL syringe.
Change to a 0.22-µm filter needle.
Transfer the vancomycin solution into the ophthalmic bottle with the remaining artificial tears.
Shake well to mix.
Quality-Control Procedures — Visually inspect for physical appearance of formulation and container closure integrity (no leakage, cracks in container, or improper seals).
Labeling Requirements — Extemporaneously compounded preparation. For ophthalmic use only. Store at room temperature or refrigerate.
Storage Conditions/Stability — Store at room temperature or refrigerate. Stable for 10 days when refrigerated and 7 days when stored at room temperature.
Study Container Type — Ophthalmic dropper bottle
Referenced Manufacturers — Vancomycin hydrochloride injection (Vancocin, Eli Lily & Co); sterile water for injection (McGaw); artificial tears (Tears Naturale, Alcon Laboratories, Inc).
Stability-Indicating Study — Yes
Footnote — Artificial tears contain 0.3% hydroxypropyl methylcellulose, 0.1% dextran 70, 0.01% benzalkonium chloride, and 0.05% edetate disodium.
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