Clinical Pharmacokinetics

Editor: John E. Murphy
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In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, PharmD, FASHP, FCCP, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely used textbook and reference.

Clinical Pharmacokinetics, 6th Edition, includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. There is also a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book.

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The Expanded 6th Edition of Clinical Pharmacokinetics

In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, PharmD, FASHP, FCCP, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely used textbook and reference. 

Clinical Pharmacokinetics, 6th Edition, includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. There is also a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book. 

Everything you need to know about PK today:

  • Drugs, dosing, and therapeutic monitoring
  • Drug concentration measurements
  • New chapter on the impact of pharmacogenomics
  • Neonatal, pediatric, obese, and geriatric dosing 
  • Dosing in renal disease and creatinine clearance estimation
  • Drugs sorted by family and as single drugs

Written in a straightforward style, with numerous charts and lists, the sixth edition makes complicated dosing and monitoring information easy to find and understand. Whether you are a student or practitioner, it is a resource you will turn to for reliable guidance throughout your pharmacy career.

John E. Murphy, PharmD, FASHP, FCCP

John E. Murphy is Professor of Pharmacy Practice and Science and Associate Dean for Academic and Professional Affairs at the College of Pharmacy, and Professor of Family and Community Medicine at the College of Medicine, the University of Arizona in Tucson. He is also an Honorary Professor at the University of Otago School of Pharmacy in Dunedin, New Zealand. He received his BS in Pharmacy and PharmD degrees from the University of Florida in Gainesville, where he was a recipient of the Distinguished Pharmacy Alumnus Award in 1998. 

Long active in pharmacy organizations, Dr. Murphy was president of the American College of Clinical Pharmacy (ACCP) from 2008-2009, the American Society of Health-System Pharmacists (ASHP) from 1997-1998, and the Georgia Society of Hospital Pharmacists.

Dr. Murphy has published over 200 papers, ~ 100 abstracts, six editions of Clinical Pharmacokinetics, and the Resident Survival Guide. He is co-editor of the Pharmacotherapy Self-Assessment Program (PSAP 8) for ACCP with Mary Lee and is currently writing a new basic and applied pharmacokinetic self-assessment textbook for ASHP. He is a frequent speaker at international, national, and statewide continuing education meetings. 

Among various professional and teaching awards received over the years, Dr. Murphy received the Award for Sustained Contributions to the Literature of Pharmacy Practice from the ASHP Research and Education Foundation in 2003 and the Education Award from ACCP in 2012.

The Pharmaceutical Journal 9 AUG 2017

By Laurence A. Goldberg

This book was originally written to help practitioners predict drug doses to achieve target drug concentrations from doses administered to patients. Important chapters on rational use of drug concentration measurements, dosing in overweight and obese patients, dosing considerations for a wider variety of drugs used in neonatal, pediatric and geriatric patients, drug dosing in renal disease and creatinine clearance estimation have been added over the years. The book offers information for medicines that require an understanding of individual patients’ probable or actual drug concentrations to achieve medication effectiveness and safety.

In this expanded 6th edition, authors have taken advantage of advances in knowledge to update the chapters. In many cases, more judicious monitoring of drug concentrations is suggested compared with the earlier editions. In some cases, the dosing approaches are radically different and, in others, new prediction approaches are available that have been tested in larger numbers of patients. Many chapters have been updated to take into account emerging pharmacogenetics knowledge.

Pharmacogenomic issues are increasingly important in decisions about drug dosing or which patients should receive certain drugs. A new chapter has been added to help interpret issues related to applying pharmacogenomics to drug dosing.

General pharmacokinetic principles are discussed in the introductory chapter, including the reasons why some drug concentration measurements fall outside the expected range of population estimates. This chapter also includes a glossary of pharmacokinetic terms, selected pharmacokinetic symbols and a series of pharmacokinetic equations.

The main chapters are devoted to those drugs that require careful monitoring, such as aminoglycosides, antiepileptics, antidepressants, antirejection agents, carbamazepine, ethosuximide, digoxin, lithium, heparin, warfarin and several others.

Typically, each chapter includes the usual dose range, the bioavailability of the dose forms, general pharmacokinetic information (absorption, distribution, elimination, metabolism, protein binding), clearance, volume of distribution, half-life and time to steady state, therapeutic range, dosing strategies, sampling times, pharmacodynamic monitoring, drug-drug interactions, pharmacodynamic interactions, drug-disease interactions and references. A large number of references are cited at the end of each chapter.

Chapter authors represent a broad range of pharmacy practice, including those in clinical practice, academia and in medical departments of pharmaceutical companies.

This book shows practitioners and students how to apply pharmacokinetic principles to drug therapy in day-to-day practice. It is an excellent reference source, offering practitioners the key principles in pharmacokinetics and the application of these principles in drug therapy. Because the tables cover both international and traditional units for drugs and laboratory tests, the book can be used across the world. All who work in this area of practice should find this excellent book of great value.