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RankDrug NameTotal Prescriptions (2016)
1Levothyroxine114,344,324
2Lisinopril110,611,324
3Atorvastatin96,942,508
4Metformin Hydrochloride81,305,415
5Amlodipine Besylate75,201,622
6Metoprolol74,019,645
7Omeprazole70,626,980
8Simvastatin65,144,488
9Losartan Potassium49,281,054
10Albuterol47,109,711
11Gabapentin44,154,514
12Hydrochlorothiazide43,472,270
13Acetaminophen; Hydrocodone Bitartrate43,109,574
14Sertraline Hydrochloride37,105,238
15Furosemide32,692,726
16Fluticasone29,899,932
17Acetaminophen29,325,845
18Amoxicillin28,117,284
19Alprazolam27,030,725
20Atenolol26,739,322
21Citalopram26,387,590
22Insulin Glargine26,201,314
23Montelukast25,326,687
24Trazodone Hydrochloride25,300,258
25Pantoprazole Sodium25,270,699
26Escitalopram Oxalate25,240,490
27Pravastatin Sodium24,666,149
28Bupropion23,811,613
29Fluoxetine Hydrochloride23,729,286
30Carvedilol23,338,866
31Prednisone23,242,849
32Tamsulosin Hydrochloride22,533,461
33Potassium22,380,348
34Clopidogrel Bisulfate21,398,662
35Ibuprofen21,329,751
36Meloxicam21,290,692
37Rosuvastatin Calcium19,917,442
38Aspirin19,753,190
39Tramadol Hydrochloride19,479,377
40Zolpidem Tartrate19,102,809
41Warfarin18,718,271
42Clonazepam18,675,679
43Propranolol Hydrochloride18,416,025
44Glipizide17,884,980
45Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate17,363,796
46Cyclobenzaprine16,170,425
47Methylphenidate15,599,244
48Duloxetine15,377,184
49Azithromycin15,292,543
50Ranitidine15,285,992
51Venlafaxine Hydrochloride15,283,793
52Allopurinol15,227,146
53Hydrochlorothiazide; Lisinopril14,862,223
54Oxycodone14,693,850
55Ethinyl Estradiol; Norethindrone14,614,505
56Ergocalciferol14,608,444
57Lorazepam14,317,316
58Ethinyl Estradiol; Norgestimate13,426,358
59Estradiol13,361,413
60Hydrochlorothiazide; Triamterene12,735,626
61Glimepiride12,432,147
62Fluticasone Propionate; Salmeterol Xinafoate12,314,689
63Diltiazem Hydrochloride12,257,572
64Paroxetine12,222,861
65Loratadine12,085,215
66Spironolactone11,991,114
67Fenofibrate11,767,185
68Naproxen11,470,076
69Esomeprazole11,417,610
70Lamotrigine11,276,212
71Metronidazole11,169,357
72Lovastatin11,000,895
73Alendronate Sodium10,576,011
74Cetirizine Hydrochloride10,307,139
75Finasteride10,300,054
76Clonidine10,253,268
77Budesonide; Formoterol10,195,375
78Diclofenac9,907,530
79Latanoprost9,879,869
80Hydrochlorothiazide; Losartan Potassium9,772,428
81Bacitracin; Neomycin; Polymyxin B9,200,340
82Sitagliptin Phosphate9,164,964
83Pregabalin9,074,950
84Insulin Human8,947,388
85Topiramate8,846,881
86Quetiapine Fumarate8,751,996
87Insulin Aspart8,662,906
88Amitriptyline8,638,268
89Levetiracetam8,534,737
90Buspirone Hydrochloride8,456,948
91Ondansetron8,450,779
92Valsartan8,406,000
93Ferrous Sulfate8,398,923
94Enalapril Maleate8,342,017
95Tiotropium8,306,842
96Folic Acid8,276,080
97Hydroxyzine8,082,370
98Donepezil Hydrochloride7,761,701
99Lisdexamfetamine Dimesylate7,570,687
100Insulin Lispro7,544,686
101Isosorbide Mononitrate7,360,509
102Ciprofloxacin7,192,190
103Cholecalciferol; Alpha-Tocopherol7,114,696
104Benazepril Hydrochloride7,093,458
105Rivaroxaban7,058,562
106Sulfamethoxazole; Trimethoprim6,879,928
107Cephalexin6,785,958
108Oxybutynin6,735,604
109Drospirenone; Ethinyl Estradiol6,681,736
110Doxycycline6,640,671
111Ropinirole Hydrochloride6,628,478
112Diazepam6,606,345
113Hydrocodone Bitartrate6,591,400
114Amoxicillin; Clavulanate Potassium6,579,603
115Sumatriptan6,564,780
116Pioglitazone6,563,097
117Ethinyl Estradiol; Levonorgestrel6,441,019
118Tizanidine6,401,817
119Thyroid6,363,773
120Celecoxib6,269,150
121Insulin Detemir6,227,661
122Triamcinolone6,077,301
123Apixaban5,833,149
124Baclofen5,708,865
125Famotidine5,702,253
126Nebivolol Hydrochloride5,686,450
127Docusate5,585,832
128Mirtazapine5,547,697
129Divalproex Sodium5,484,270
130Verapamil Hydrochloride5,424,766
131Aripiprazole5,186,998
132Gemfibrozil5,068,993
133Desogestrel; Ethinyl Estradiol5,062,634
134Hydrochlorothiazide; Valsartan5,000,778
135Hydroxychloroquine Sulfate4,965,681
136Prednisolone4,942,861
137Cyanocobalamin4,941,184
138Hydralazine Hydrochloride4,888,742
139Omega-3-acid Ethyl Esters4,841,513
140Amlodipine Besylate; Benazepril Hydrochloride4,829,728
141Lansoprazole4,805,894
142Timolol4,684,226
143Hydrocortisone4,634,998
144Ezetimibe4,570,245
145Digoxin4,470,645
146Testosterone4,413,016
147Memantine Hydrochloride4,388,334
148Methylprednisolone4,382,399
149Estrogens, Conjugated4,245,842
150Adalimumab4,245,501
151Clindamycin4,223,619
152Methotrexate4,208,091
153Ramipril4,206,514
154Nifedipine4,152,353
155Methylcellulose (4000 Mpa.S)4,092,001
156Guanfacine4,022,949
157Doxazosin Mesylate4,010,324
158Morphine3,989,646
159Risperidone3,975,563
160Promethazine Hydrochloride3,928,732
161Levofloxacin3,910,492
162Meclizine Hydrochloride3,906,199
163Levocetirizine Dihydrochloride3,868,302
164Olmesartan Medoxomil3,805,975
165Mometasone3,780,867
166Albuterol Sulfate; Ipratropium Bromide3,774,880
167Brimonidine Tartrate3,764,084
168Valacyclovir3,730,423
169Terazosin3,728,582
170Solifenacin Succinate3,630,386
171Irbesartan3,615,078
172Glyburide3,591,159
173Fluconazole3,553,998
174Chlorthalidone3,551,730
175Carbidopa; Levodopa3,535,782
176Beclomethasone3,519,550
177Polyethylene Glycol 33503,503,811
178Dicyclomine Hydrochloride3,502,152
179Magnesium3,473,024
180Nitroglycerin3,472,539
181Carisoprodol3,405,849
182Ipratropium3,400,104
183Calcium; Cholecalciferol3,381,006
184Clobetasol Propionate3,335,235
185Temazepam3,235,550
186Nitrofurantoin3,232,274
187Methocarbamol3,229,264
188Liraglutide3,225,863
189Progesterone3,173,331
190Dexlansoprazole3,153,131
191Metformin Hydrochloride; Sitagliptin Phosphate3,150,401
192Nortriptyline Hydrochloride3,131,539
193Benzonatate3,104,318
194Canagliflozin3,102,040
195Acyclovir3,078,845
196Linagliptin3,058,866
197Carbamazepine2,982,030
198Amiodarone Hydrochloride2,934,681
199Mupirocin2,833,713
200Dorzolamide Hydrochloride; Timolol Maleate2,794,085
Source: Used with permission from Kane SP. ClinCalc Drug-Stats Database, Version 19.1. Updated 2018 Nov 24. https://clincalc.com/DrugStats (accessed 2019 Jan 10).

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